Natural Factors PCOS Care 129g

PCOS Care 129g (Care for polycystic ovary syndrome) - a natural product to support ovarian function in women with PCOS
PCOS Care is an innovative specialized formula developed to improve metabolic and ovarian function in women of childbearing age affected by Polycystic Ovary Syndrome. Regular intake of the product normalizes the menstrual cycle, lowers testosterone levels, the manifestations of acne and hirsutism, normalizes blood sugar levels, and optimizes fertility and the likelihood of successful conception.

PCOS Care contains Myo-inositol, d-chiro-inositol, folic acid, and vitamin B 12 - a combination of proven benefits for women's health. Recommended for: Polycystic ovary syndrome, elevated levels of androgens (male sex hormones), reproductive problems, elevated insulin levels and disorders of insulin sensitivity.

How does PCOS Care work?
contributes to the normalization of the production of insulin, luteinizing hormone (LH) and androgens;
helps to restore the regular menstrual cycle and ovarian function, and stimulates ovulation;
helps maintain the quality of eggs (oocytes) and reduce the number of unfit eggs;
provides benefits for infertile women who wish to conceive in vitro (IVF or ICSI);
favorably affects the endocrine and metabolic parameters;
helps maintain normal blood pressure levels and improve the body's sensitivity to insulin;
has a beneficial effect on the ovaries at the metabolic and hormonal levels.
Myo-inositol and D-chiro-inositol are naturally occurring forms of inositol, a vitamin-like substance that maintains the structural integrity of cell membranes. In the product PCOS Care  myo-inositol and d-chiro-inositol are presented in their most effective physiological ratio - 40: 1.

PCOS Care 129g

The product does not contain colorants, preservatives or sweeteners, GMOs and mass allergens such as dairy and seafood, gluten, eggs, soy or nuts. Suitable for vegetarians and vegans. The non-flavored powder allows twice-daily dosing with a preferred food or beverage.

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age. It is characterized by menstrual abnormalities, clinically manifested hyperandrogenism, multiple abnormal cysts and ovarian enlargement. Polycystic ovary syndrome is also the leading cause of infertility due to menstrual dysfunction.

Studies have shown that altered insulin signal transduction in patients with Polycystic Ovary Syndrome can lead to insulin resistance, which in turn can cause abnormal ovarian steroidogenesis with elevated testosterone levels. Insulin resistance and compensatory hyperinsulinemia affect about 65-70% of women with PCOS, 70-80% of whom are overweight.

Overweight women and Polycystic Ovary Syndrome benefit from treatment with insulin-sensitive drugs that reduce serum androgen levels and restore ovulation. The problem is that these medications also have side effects, including gastrointestinal discomfort, nausea, bloating, gas and diarrhea, and weight gain. It has also been found that their use is generally associated with an increased risk of arterial disease and myocardial infarction. Long-term use of oral contraceptives and antiandrogens in PCOS can also have negative effects.

A number of studies have shown that therapy with the two inositol stereoisomers, myo-inositol and D-chiro-inositol, improves the clinical picture in women with polycystic ovary syndrome and overweight, and reduces the risk of metabolic syndrome without causing side effects. Recently, more and more specialists are combining myo-inositol and D-chiro-inositol with conventional treatment, as they effectively counteract the endocrine-metabolic disorders accompanying PCOS.

Myo-inositol and D-chiro-inositol play a key role in many cellular processes controlling glucose metabolism. They act as insulin sensitisers, which enhance physiological insulin receptor activity and lower serum glucose levels. Myo-inositol and D-chiro-inositol reduce serum insulin and testosterone levels, and restore normal ovulation in women with polycystic ovary syndrome. Elevated levels of myo-inositol in follicular fluid have been shown to play a specific role in follicle maturation and maintain egg quality.

Inositol is found in the highest concentrations in the human brain and in mammals, but plays roles in various other tissues. It is also found in some foods of animal origin, in nuts, seeds and fruits. The daily amount of inositol produced in the body is about 2-3 gr, of which at least 2 gr. are synthesized in the kidneys and several hundred mg - in the testicles. From there, inositol crosses the blood-brain barrier and enters the CNS, where it is incorporated into the structure of important phospholipids or acts as a signaling molecule. Among the physiological effects of inositol are the following:

PCOS Care 129g

participates in the binding of a number of neurotransmitters and hormones for their respective receptors, which regulates various biosynthetic and behavioral processes;
affects the release of serotonin and reduces anxiety and nervous tension caused by stress and hormonal imbalance;
lowers insulin resistance and reduces serum insulin levels and therefore reduces testosterone production caused by excess insulin.

PCOS Care 129g

What are the benefits of vitamin B12 and the active form of folic acid - 5-Methyltetrahydrofolate?

Vitamin B12. Many diseases include B12 deficiency, including obesity, insulin resistance, diabetes, infertility, and polycystic ovary syndrome. It has been found that many women with obesity, insulin resistance and PCOS have significantly lower levels of vitamin B12, so it is recommended that they get more. PCOS Care contains the bioactive vitamin of vitamin B12 - methylcobalamin, which has a high bioavailability and optimal effective action in the body.

5-Methyltetrahydrofolate (L-5-MTHF). This is the biologically active form of folic acid, characterized by an optimal degree of absorption. The inclusion of L-5-MTHF and not folic acid in this product is essential because folic acid is not active in the body but is metabolised to active methyl tetrahydrofolate by the enzyme methyl tetrahydrofolate reductase (MTHFR). The problem with this enzyme is that between 10 and 40% of people have genetic variations in the gene encoding this enzyme and significantly reduce its activity to normal. Often, the intake of pure folic acid does not significantly contribute to their health. Therefore, PCOS Care contains only the active vitamin B9 vitamin - L-5-MTHF. The active form of folic acid - 5-Methyltetrahydrofolate is required for the construction of DNA and RNA, and for the metabolism of amino acids involved in cell growth and proliferation. In various cell studies, it has been found that the active form of folic acid improves the clinical picture of PCOS and increases the chances of pregnancy and fetal wear without neural tube defects. It has a positive effect on the symptoms of PCOS, but less than that of myo-inositol. The combination of the active form of folic acid and inositol has a synergistic effect, exceeding that of the two nutrients separately.

PCOS Care 129g Ingredients:

Myo-Inositol 2000 mg 4000 mg
D-Hiro Inositol 50 mg 100 mg
PCOS Care 129g Folic acid / Folate (L-5-methyltetrahydrofolate, calcium salt) 200 µg 400 µg
Vitamin B12 (Methylcobalamin) 1.5 µg 3 (g
Rice flour (powder)

Does not contain: artificial colors, flavors, preservatives, dairy products, starch, sugar, wheat, gluten, yeast, soy, eggs, fish, shellfish, animal products, salt, nuts and GMOs. Suitable for vegans/vegetarians.

PCOS Care 129g Dosage:

Application: Contributes to the normal state of the female body, as well as to the maintenance of normal glucose metabolism. Contributes to the normal development of the fetus during the 1st trimester of pregnancy. The product is suitable for in vitro procedures.

Note: In case of pregnancy or breastfeeding, consult a doctor before use. Do not use as a substitute for a varied and complete diet. Do not exceed the recommended daily dose.

Dosage: 1 ml. (2.15 g), twice daily, dissolved in 250 ml of water.